参与原核生物DNA复制的酶类和蛋白质EnzymesandProteins-PPT精品.ppt

参与原核生物DNA复制的酶类和蛋白质EnzymesandProteins-PPT精品
DNA replication(bacteria)
Initiation
Elongation
Termination
Daughter DNA partition
* the origin of replication is defined
* replication bubble.
* Replication fork
* Unidirectional or bidirectional.
Origins
Figure 13.9 The leading strand is synthesized continuously while the lagging strand is synthesized discontinuously.
Elongation(semidiscontinuous)
termination
参与DNA复制的酶类
1、DNA聚合酶
2、DNA引发酶（DNA primase）
3、DNA连接酶
4、与DNA几何学性质相关的酶
I polA major repair enzyme
II polB minor repair enzyme
III polC replicase
IV dinB SOS repair
V umuC、D SOS repair
DNA polymerases in E.coli
DNA Polymerase I
DNA polymerase
3’ 5’ exonuclease
5’ 3’ exonuclease
Figure 13.18 DNA polymerase III holoenzyme assembles in stages, generating an enzyme complex that synthesizes the DNA of both new strands.